Combating immunosuppression in glioma

Hypoxia Potentiates Glioma-Mediated Immunosuppression

Glioblastoma multiforme (GBM) is a lethal cancer that exerts potent immune suppression. Hypoxia is a predominant feature of GBM, but it is unclear to the degree in which tumor hypoxia contributes to this tumor-mediated immunosuppression. Utilizing GBM associated cancer stem cells (gCSCs) as a treatment resistant population that has been shown to inhibit both innate and adaptive immune responses...

Glioma-associated cancer-initiating cells induce immunosuppression.

PURPOSE Glioblastoma multiforme is a lethal cancer that responds poorly to therapy. Glioblastoma multiforme cancer-initiating cells have been shown to mediate resistance to both chemotherapy and radiation; however, it is unknown to what extent these cells contribute to the profound immunosuppression in glioblastoma multiforme patients and if strategies that alter their differentiation state can...

Understanding and overcoming the immunosuppressive effects of glioma induced immunosuppression

Utilizing tumors as a source of vaccination antigens in immunotherapy has demonstrated promising results with minimal toxicity. Unfortunately, researchers have failed to overcome the overpowering suppressive effects of the tumor microenvironment. Recently we demonstrated that the proximity of the vaccination injection site to the primary tumor site dictates CD8 T-cell priming within the drainin...

Mechanisms of malignant glioma immune resistance and sources of immunosuppression.

High grade malignant gliomas are genetically unstable, heterogeneous and highly infiltrative; all characteristics that lend glioma cells superior advantages in resisting conventional therapies. Unfortunately, the median survival time for patients with glioblastoma multiforme remains discouraging at 12-15 months from diagnosis. Neuroimmunologists/oncologists have focused their research efforts t...

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